Ginkgolic Acid Inhibits Herpes Simplex Virus Type 1 Skin Infection and Prevents Zosteriform Spread in Mice
نویسندگان
چکیده
Herpes simplex virus type 1 (HSV-1) causes a lifelong latent infection with an estimated global prevalence of 66%. Primary and recurrent HSV infections are characterized by tingling sensation, followed eruption vesicles, which can cause painful erosions. Commonly used antiviral drugs against nucleoside analogues including acyclovir (ACV), famciclovir, valacyclovir. Although these reduce morbidity mortality in immunocompetent individuals, ACV-resistant strains (ACVR-HSV) have been isolated from immunocompromised patients. Thus, ACVR-HSV poses critical emerging public health concern. Recently, we reported that ginkgolic acid (GA) inhibits HSV-1 disrupting viral structure, blocking fusion, inhibiting protein synthesis. Additionally, showed GA affords broad spectrum fusion inhibition all three classes proteins, those HIV, Ebola, influenza A Epstein Barr viruses. Here report GA’s activity skin BALB/cJ mice. GA-treated mice demonstrated significantly reduced rate decreased scores compared to controls treated dimethylsulfoxide (DMSO)-vehicle. Furthermore, efficiently inhibited ACVR-HSV-1 strain 17+ vitro vivo. Since mechanism action includes virucidal inhibition, it is expected work alone or synergistically other anti-viral drugs, anticipate be effective additional cutaneous potentially systemic infections.
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ژورنال
عنوان ژورنال: Viruses
سال: 2021
ISSN: ['1999-4915']
DOI: https://doi.org/10.3390/v13010086